One of the single most important pieces of advice for any form of gambling is to set aside a sum of money that is exclusively for the relevant activity. It should be money that is not needed for anything else, that you can afford to lose, and that you are comfortable putting at risk. This money will be known as your bankroll, and it's effectively the most important tool a bettor has at his disposal.
You can also make a football moneyline bet on either team, simply picking which team you believe will win the game outright. The moneyline price on your team will determine how much you win on your bet. For example, Team A is a -360 favorite on the moneyline and opponent Team B is a +300 underdog. That means for every dollar you want to win on the Team A moneyline, you must bet $3.60. However, a bet on the Team B moneyline will win $3 for every $1 wagered.
Here's an example: Imagine that using the money line above with the White Sox and the Astros, you want to win about $100. If you place your bet on the favored White Sox, you will pay the bookie $120. If you win, you get your $120 back, plus $100 in winnings. If you lose, the bookie keeps your $120 (technically, bookies collect on losing bets after the game most of the time, but for our example we'll assume the bet is prepaid). If you bet $100 on the Astros, you'll get $110 in winnings if they win, and only lose $100 if they lose.

The last number in the top two rows of our sports line example is known as the money line. If you’re not interested in betting on the point spread, you can wager on a team to win outright. The plus sign next to the underdog (in our case, the Giants) indicates how much money you’ll earn for every $100 you bet on the money line. Conversely, the minus sign next to the favorite’s line tells you how much you have to wager in order to win $100. In our example, a $100 wager on the Giants earns you $300 should they pull off the upset, while a bet of $405 on the Cowboys will net you an extra $100. Representing odds in units of $100 makes placing different size bets easy; if you want to bet $10 on the Giants, you stand to earn $30 if they win, while a $40.50 bet on the Cowboys will net you an additional $10.
With some betting sites odds, certain games are priced differently than risking $1.10 to win $1.00 (which is called -110 odds). For example, you might see the Giants priced at -105 and +7 in a game against the Jets. Now, you only have to risk $1.05 to win $1.00. This is obviously better odds, but it's very likely that they will lose by exactly seven to give you a push. Taking -110 and +7.5 with an alternative bookmaker is actually the better bet.
Point Spread: The point spread remains the favorite way to wager on pro football, regardless of how many new forms of wagering come on stream. It’s called the line or spread and it’s known as betting ‘sides.’ The common misconception is that Las Vegas sets the spread as its best guess at the margin of victory. But really, it's a number they feel that is a perfect balance and will see an equal number of people to bet the underdog as on the favorite. A negative value like -6.5 means that team is favored by 6.5 points. So deduct 6.5 points from their total score. A positive value on the same game would be +6.5 (add 6.5 points to their final score) and would make that team an underdog of 6.5 points. The favorite must win by at least seven points to cover the spread. The underdog can lose by six points and still cover.
×