The -110 on either side is like paying a tax or commission to the sportsbook. Bettors would pay 10 percent (aka juice) to the sportsbook, which is essentially a fee for brokering the wager. So, the -110 indicates that a bettor must risk $110 to win $100. Some sportsbooks will even reduce the juice for you which means you can earn the same $100 payout but risk less money to do it.
The spread - The point spread is used in high-scoring sports like football and basketball. It is basically a handicap used to make all games competitive in the eyes of bettors. The spread gives one team an advantage of a few points. Standard notation for the point spread shows the favored team first, followed by a negative number (the actual spread). The home team is shown in capital letters. So if Buffalo was playing against Green Bay in Green Bay, and they were favored to win by seven points, it would look like this:
When you’re looking at over under bets, what you need to know is that that’s the combined score of the two teams for a game. In this case, it doesn’t matter who wins the game. All that matters is the final score. For example: let’s say that the New York Yankees are playing the Boston Red Sox and the total is 9.5. It doesn’t matter who wins the game but if the two teams combine for a total score of eight runs, say with a final score of Boston winning 5-3, then the game goes under. Or if the two teams combined for 10 runs – no matter who wins – then the game goes over. So when you’re looking at the odds and you see a total next to the moneyline or point spread, that tells you the over-under that is set for the game and you have to decide whether it will go over that set amount or under.
A point spread, or “the line,” is a number set by oddsmakers to give an advantage to one team and a disadvantage to another team based on the margin of victory or defeat for the two teams. The favorite team is giving up points for purposes of the wager, meaning they not only have to win, but they have to win by X amount of points. The underdog team is getting points for purposes of the wager, meaning they can still lose the game, but they must lose by less than X amount of points.

Point Spread: The point spread remains the favorite way to wager on pro football, regardless of how many new forms of wagering come on stream. It’s called the line or spread and it’s known as betting ‘sides.’ The common misconception is that Las Vegas sets the spread as its best guess at the margin of victory. But really, it's a number they feel that is a perfect balance and will see an equal number of people to bet the underdog as on the favorite. A negative value like -6.5 means that team is favored by 6.5 points. So deduct 6.5 points from their total score. A positive value on the same game would be +6.5 (add 6.5 points to their final score) and would make that team an underdog of 6.5 points. The favorite must win by at least seven points to cover the spread. The underdog can lose by six points and still cover.

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