On a moneyline bet of -300, you’ll need to win your bet 75% of the time just to break even. When your odds jump even higher to -400, you’ll need to win your bet 80% of the time to show a profit. You are risking a lot to win very little and even though a large favorite will win most of the time, when they do lose, you will find yourself out a lot of money. I try to stay away from large favorite moneylines, because the amount risked is very high and the payoff is low.

A money line, used in baseball and hockey, takes the place of a point spread. Money line betting is simply wagering on the contest based on a given price rather than a point spread. The team wagered on has to win the game outright, regardless of the score. The minus sign (e.g.-130) always indicates the favorite and the amount you must bet to win $100. The plus sign (e.g.+120) always indicates the underdog and the amount you win for every $100 bet. Using this example, therefore, you would bet $130 to win $100 on the favorite, while for the underdog you would bet $100 to win $120.
The main goal for each sportsbook is to set the best line possible in order to create even action on both sides of the game. In a perfect world, the book would have 50 percent of the handle come in on the favorite and 50 percent of the action come in on the underdog. If this happens, the sportsbook would be guaranteed a profit because of the 10 percent vig they charge on most point spread wagers. When a book has serious one-sided action, they will attempt to counter that by moving the line in the direction that's taking the most money and try to entice bettors into betting on the other side.
The point spread, which is sometimes referred to as the “handicap”, is the number of points taken from the favorite, or given to the underdog, in order to open up the chances of either team winning the wager evenly. In most games, there’s usually a team that is more likely to win, based on a number of statistical factors. If the only kind of wager available was on who would win between a very strong team and a poor team, it wouldn’t be all that exciting. The point spread was designed to make betting much more interesting, since it allows a bet on the losing team to win you money. How? Let’s break down an example: